Phagocytosis is a primary determinant of pulmonary clearance of clinical Klebsiella pneumoniae isolates.

ABSTRACT:

Introduction

Klebsiella pneumoniae (Kp) is a common cause of hospital-acquired pneumonia. Although previous studies have suggested that evasion of phagocytic uptake is a virulence determinant of Kp, few studies have examined phagocytosis sensitivity in clinical Kp isolates.

Methods

We screened 19 clinical respiratory Kp isolates that were previously assessed for mucoviscosity for their sensitivity to macrophage phagocytic uptake, and evaluated phagocytosis as a functional correlate of in vivo Kp pathogenicity.

Results

The respiratory Kp isolates displayed heterogeneity in the susceptibility to macrophage phagocytic uptake, with 14 out of 19 Kp isolates displaying relative phagocytosis-sensitivity compared to the

SUBMITTER: van der Geest R 

PROVIDER: S-EPMC10086180 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature