Development and validation of a nonenhanced CT based radiomics model to detect brown adipose tissue.

ABSTRACT: Purpose: It has been reported that brown adipose tissue (BAT) has a protective effect regarding cardiovascular disease. Positron emission tomography-computed tomography (PET-CT) is the reference method for detecting active BAT; however, it is not feasible to screen for BAT due to the required radionuclides and high-cost. The purpose of this study is to develop and validate a nonenhanced CT based radiomics model to detect BAT and to explore the relationship between CT radiomics derived BAT and cardiovascular calcification. Patients and methods: 146 patients undergoing ¹⁸F-FDG PET-CT were retrospectively included from two centers for model development (n = 86) and external validation (n = 60). The data for the model development were randomly divided into a training c

SUBMITTER: Li J 

PROVIDER: S-EPMC10086200 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature