Defining the key intrahepatic gene networks in HCV infection driven by sex.

ABSTRACT:

Objective

The transcriptional response in the liver during HCV infection is critical for determining clinical outcomes. This issue remains relatively unexplored as tissue access to address this at scale is usually limited. We aimed to profile the transcriptomics of HCV-infected livers to describe the expression networks involved and assess the effect on them of major predictors of clinical outcome such as IFNL4 (interferon lambda 4) host genotype and sex.

Design

We took advantage of a large clinical study of HCV therapy accompanied by baseline liver biopsy to examine the drivers of transcription in tissue samples in 195 patients also genotyped genome-wide for host and viral single nucleotide polymorphisms. We addressed the role of host factors (disease status, sex, genotype,

SUBMITTER: Marchi E 

PROVIDER: S-EPMC10086281 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature