Traumatic encephalopathy syndrome: application of new criteria to a cohort exposed to repetitive head impacts.

ABSTRACT:

Objective

To examine the characteristics of those who fulfil the recent National Institute of Neurological Disease and Stroke (NINDS) Consensus Diagnostic Criteria for Traumatic Encephalopathy Syndrome (TES) and test whether they show differences in MRI-based regional brain volumes, cognitive domains, and certain plasma biomarkers.

Methods

Professional fighters 35 years of age or older and/or retired were included. Participants were categorised as either having TES (TES+) or not (non-TES). TES+ participants were further subtyped by their cognitive profile. Multiple linear regression models were used to compare MRI-based regional brain volumes, cognitive performance, plasma tau and neurofilament light levels between TES- and TES+ groups.

Results

176 participants (110 b

SUBMITTER: Ritter A 

PROVIDER: S-EPMC10086298 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature