Clinical and genetic factors associated with radiographic damage in patients with ankylosing spondylitis.

ABSTRACT:

Objectives

To identify clinical and genetic factors associated with severe radiographic damage in patients with ankylosing spondylitis (AS).

Methods

We newly generated genome-wide single nucleotide polymorphism data (833K) for 444 patients with AS. The severity of radiographic damage was assessed using the modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS). To identify clinical and genetic factors associated with severe radiographic damage, multiple linear regression analyses were performed. Human AS-osteoprogenitor and control-osteoprogenitor cells were used for functional validation.

Results

The significant clinical factors of final mSASSS were baseline mSASSS (β=0.796, p=3.22×10^-75), peripheral joint arthritis (β=-0.246, p=6.85×10<

SUBMITTER: Nam B 

PROVIDER: S-EPMC10086301 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature