Identification of calcium metabolism related score associated with the poor outcome in papillary thyroid carcinoma.

ABSTRACT:

Introduction

Papillary thyroid carcinoma is a type of thyroid cancer that exhibits significant variability in prognosis. Extensive research indicates that the impaired signaling of 1,25(OH)2D3-VDR may be a crucial factor in the development and progression of PTC.

Methods

To investigate this further, Integrated analysis mRNA expression information from The Cancer Genome Atlas and GEO, we compared gene expression in cancer and normal tissues and identified differentially expressed genes (DEGs). Through this analysis, we identified DEGs and calculated risk estimates for seven genetic markers.

Results

Subsequently, we constructed predictive models using LASSO-Cox regression to test the predictive value of these markers. Our results revealed that 64 calcium metabolism-rela

SUBMITTER: Hu C 

PROVIDER: S-EPMC10086330 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature