CD226 identifies functional CD8⁺T cells in the tumor microenvironment and predicts a better outcome for human gastric cancer.

ABSTRACT: It is well-known that CD226 serves as a critical activating receptor on various immune cells, such as lymphocytes and monocytes, and it is suggested to promote anti-tumor immunity in the tumor microenvironment (TME). Herein, we showed a crucial regulatory role of CD226 in CD8⁺T cell-mediated anti-tumor response in TME of human gastric cancer (GC). Specifically, the increased CD226 expression in cancer tissues was significantly associated with better clinical outcomes in GC patients. Moreover, the increased infiltrating CD226⁺CD8⁺T cells and the increased ratio of infiltrating CD226⁺CD8⁺T cells in CD8⁺T subpopulation within cancer tissues could also be valuable prognostic predictors for GC patients. Mechanically, the assay fo

SUBMITTER: Huang H 

PROVIDER: S-EPMC10086426 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature