Association of antihypertensive drugs with fracture and bone mineral density: A comprehensive drug-target Mendelian randomization study.

ABSTRACT:

Background

Observational studies have investigated the associations between antihypertensive drugs and fracture risk as well as bone mineral density (BMD), but yielding controversial results.

Methods

In this study, a comprehensive drug-target Mendelian randomization (MR) analysis was conducted to systematically examine the associations between genetic proxies for eight common antihypertensive drugs and three bone health-related traits (fracture, total body BMD [TB-BMD], and estimated heel BMD [eBMD]). The main analysis used the inverse-variance weighted (IVW) method to estimate the causal effect. Multiple MR methods were also employed to test the robustness of the results.

Results

The genetic proxies for angiotensin receptor blockers (ARBs) were associated with a redu

SUBMITTER: Huang X 

PROVIDER: S-EPMC10086430 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature