High-fat diet causes undesirable bone regeneration by altering the bone marrow environment in rats

ABSTRACT:

Objective

Diet structure has changed greatly over the last few decades, and high-calorie diets have become an integral part of people’s daily diet, as well as the important cause of obesity in society. Several organ systems, including the skeletal system, are seriously affected by high-fat-diets (HFD) in the world. There is, however, still a lack of knowledge about the effects of HFD on bone regeneration and the possible mechanisms involved. In this study, the difference in bone regeneration between rats under HFD and low-fat-diets (LFD) was evaluated by monitoring the process of bone regeneration in distraction osteogenesis (DO) model animals, as well as the possible mechanisms.

Methods

A total of 40 Sprague Dawley (SD) rats (5 weeks old) were randomly divided into HFD g

SUBMITTER: Cai F 

PROVIDER: S-EPMC10086432 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature