Th2 high and mast cell gene signatures are associated with corticosteroid sensitivity in COPD.

ABSTRACT:

Rationale

Severe asthma and chronic obstructive pulmonary disease (COPD) share common pathophysiological traits such as relative corticosteroid insensitivity. We recently published three transcriptome-associated clusters (TACs) using hierarchical analysis of the sputum transcriptome in asthmatics from the Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes (U-BIOPRED) cohort comprising one Th2-high inflammatory signature (TAC1) and two Th2-low signatures (TAC2 and TAC3).

Objective

We examined whether gene expression signatures obtained in asthma can be used to identify the subgroup of patients with COPD with steroid sensitivity.

Methods

Using gene set variation analysis, we examined the distribution and enrichment scores (ES) of the 3 TACs in the tr

SUBMITTER: Faiz A 

PROVIDER: S-EPMC10086461 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature