Gestational diabetes is driven by microbiota-induced inflammation months before diagnosis.

ABSTRACT:

Objective

Gestational diabetes mellitus (GDM) is a condition in which women without diabetes are diagnosed with glucose intolerance during pregnancy, typically in the second or third trimester. Early diagnosis, along with a better understanding of its pathophysiology during the first trimester of pregnancy, may be effective in reducing incidence and associated short-term and long-term morbidities.

Design

We comprehensively profiled the gut microbiome, metabolome, inflammatory cytokines, nutrition and clinical records of 394 women during the first trimester of pregnancy, before GDM diagnosis. We then built a model that can predict GDM onset weeks before it is typically diagnosed. Further, we demonstrated the role of the microbiome in disease using faecal microbiota transplant

SUBMITTER: Pinto Y 

PROVIDER: S-EPMC10086485 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature