Loss of smelling is an early marker of aging and is associated with inflammation and DNA damage in C57BL/6J mice.

ABSTRACT: Olfactory dysfunction is a prevalent symptom and an early marker of age-related neurodegenerative diseases in humans, including Alzheimer's and Parkinson's Diseases. However, as olfactory dysfunction is also a common symptom of normal aging, it is important to identify associated behavioral and mechanistic changes that underlie olfactory dysfunction in nonpathological aging. In the present study, we systematically investigated age-related behavioral changes in four specific domains of olfaction and the molecular basis in C57BL/6J mice. Our results showed that selective loss of odor discrimination was the earliest smelling behavioral change with aging, followed by a decline in odor sensitivity and detection while odor habituation remained in old mice. Compared to behavioral changes related

SUBMITTER: Dan X 

PROVIDER: S-EPMC10086518 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature