Bifidobacterium longum supplementation improves age-related delays in fracture repair.

ABSTRACT: Age-related delays in bone repair remains an important clinical issue that can prolong pain and suffering. It is now well established that inflammation increases with aging and that this exacerbated inflammatory response can influence skeletal regeneration. Recently, simple dietary supplementation with beneficial probiotic bacteria has been shown to influence fracture repair in young mice. However, the contribution of the gut microbiota to age-related impairments in fracture healing remains unknown. Here, we sought to determine whether supplementation with a single beneficial probiotic species, Bifidobacterium longum (B. longum), would promote fracture repair in aged (18-month-old) female mice. We found that B. longum supplementation accelerated bony callus formation which improved mechani

SUBMITTER: Roberts JL 

PROVIDER: S-EPMC10086533 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature