Metabolic rewiring in keratinocytes by miR-31-5p identifies therapeutic intervention for psoriasis.

ABSTRACT: Besides genetic alterations, the cellular environment also determines disease onset and progression. When different cell types contribute to disease outcome, this imposes environmental challenges as different cell types likely differ in their extracellular dependencies. Hsa-microRNA-31-5p (miR-31) is highly expressed in keratinocytes of psoriatic skin, and we show that expression in keratinocytes is induced by limited glucose availability and enables increased survival under limiting glucose conditions by increasing glutamine metabolism. In addition, miR-31 expression results in not only secretion of specific metabolites (aspartate and glutamate) but also secretion of immunomodulatory factors. We show that this miR-31-induced secretory phenotype is sufficient to induce Th17 cell differenti

SUBMITTER: Wang MJ 

PROVIDER: S-EPMC10086589 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature