Metabolically (un)healthy obesity and risk of obesity-related cancers: a pooled study.

ABSTRACT:

Background

Studies of obesity with or without metabolic aberrations, commonly termed metabolically unhealthy or healthy obesity, in relation to cancer risk are scarce.

Methods

We investigated body mass index (normal weight, overweight, obesity) jointly and in interaction with metabolic health status in relation to obesity-related cancer risk (n = 23 630) among 797 193 European individuals. A metabolic score comprising mid-blood pressure, plasma glucose, and triglycerides was used to define metabolically healthy and unhealthy status. Hazard ratios (HRs) and multiplicative interactions were assessed using Cox regression, and additive interactions were assessed using the relative excess risk for interaction. All statistical tests were 2-sided.

Results

Metabolically unhea

SUBMITTER: Sun M 

PROVIDER: S-EPMC10086630 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature