Efficacy and tolerability of zinc acetate for treatment of chronic refractory cough: pilot randomised futility trial.

ABSTRACT:

Background

Cough is the most reported symptom in the United States, with chronic refractory cough representing significant morbidity to patients. Zinc acetate may have beneficial effects in the cough reflex pathway. We sought to assess the safety and efficacy of zinc acetate in the management of chronic refractory cough.

Study design and methods

This was a randomised, placebo-controlled, parallel-design pilot trial of individuals with chronic refractory cough. The effects of 6 weeks of zinc acetate versus placebo on quality of life and symptoms as measured by the Cough Quality-of-Life Questionnaire (CQLQ), Leicester Cough Questionnaire (LCQ), cough visual analogue score (C-VAS) and Global Assessment of Change in Cough (GACC) scores were evaluated. A futility analysis

SUBMITTER: Balasubramanian A 

PROVIDER: S-EPMC10086688 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature