Association of genetic risk and lifestyle with incident adult-onset asthma in the UK Biobank cohort.

ABSTRACT:

Background

Both genetic and lifestyle factors contribute to the development of asthma, but whether unfavourable lifestyle is associated with similar increases in risk of developing asthma among individuals with varying genetic risk levels remains unknown.

Methods

A healthy lifestyle score was constructed using body mass index, smoking status, physical activities and dietary pattern to further categorise into ideal, intermediate and poor groups. Genetic risk of asthma was also categorised as three groups based on the tertiles of polygenic risk score established using 212 reported and verified single-nucleotide polymorphisms of European ancestry in the UK Biobank study. We examined the risk of incident asthma related with each lifestyle level in each genetic risk group by Cox

SUBMITTER: Liang H 

PROVIDER: S-EPMC10086697 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature