Silicate ions as soluble form of bioactive ceramics alleviate aortic aneurysm and dissection.

ABSTRACT: Aortic aneurysm and dissection (AAD) are leading causes of death in the elderly. Recent studies have demonstrated that silicate ions can manipulate multiple cells, especially vascular-related cells. We demonstrated in this study that silicate ions as soluble form of bioactive ceramics effectively alleviated aortic aneurysm and dissection in both Ang II and β-BAPN induced AAD models. Different from the single targeting therapeutic drug approaches, the bioactive ceramic derived approach attributes to the effect of bioactive silicate ions on the inhibition of the AAD progression through regulating the local vascular microenvironment of aorta systematically in a multi-functional way. The in vitro experiments revealed that silicate ions did not only alleviate senescence and inflammation

SUBMITTER: Que Y 

PROVIDER: S-EPMC10086764 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature