Construction of immune cell infiltration score model to assess prognostic ability of tumor immune environment in lung adenocarcinoma.

ABSTRACT:

Objectives

The immune cell infiltration (ICI) in the tumor microenvironment (TME) can provide a reference for prognosis after immunotherapy. We aim to establish an ICI scoring model and evaluate its predictive ability for the immunotherapy efficacy and the prognosis in lung adenocarcinoma (LUAD) patients.

Methods

We developed and analyzed the landscape of infiltrative immune cells based on the CIBERSORT and ESTIMATE algorithms. Then, three clusters of LUAD patients were discerned from TCGA-LUAD and GSE11969 data. Furthermore, two gene clusters were classified based on the PCA.

Results

LUAD patients with better prognoses tend to have higher immune checkpoint expression and immune/stromal scores. There is a correlation between TMB and ICI, and their relationship deserve

SUBMITTER: Tian J 

PROVIDER: S-EPMC10086903 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature