Multi-omics integrative analysis reveals the role of tumor necrosis factor superfamily member 4 in keloidal scarring.

ABSTRACT:

Objectives

To identify aberrantly expressed immune molecules in keloids and to explore their possible biologic significance.

Methods

Immune molecules with abnormal expression were identified based on immune gene sequencing of keloids, microarray datasets and high-throughput sequencing datasets and methylation microarray datasets from the Gene Expression Omnibus (GEO) database, and real-time quantitative PCR analysis.

Results

Upregulation of tumor necrosis factor superfamily member 4 (TNFSF4) in keloids was identified. Enrichment analysis found that high TNFSF4 expression was associated with immune processes, such as regulation of neutrophil chemotaxis, dendritic cell chemotaxis, and antigen processing and presentation. Single-cell RNA sequencing (scRNA) results sugges

SUBMITTER: Xia Y 

PROVIDER: S-EPMC10086931 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature