Dataset Information

Retrospective study of 20 cats surgically treated for insulinoma.

ABSTRACT:

Objective

To report the clinical signs, histopathology results, and prognostic factors for outcomes following excision for feline insulinoma (INS).

Study design

Retrospective study.

Sample population

Twenty client-owned cats.

Methods

Medical records from 2006 to 2020 were reviewed by Veterinary Society of Surgical Oncology members for cats with hypoglycemia resulting from INS, with surgical excision and follow up. Clinical signs and histopathology results were summarized. Factors potentially related to disease-free interval (DFI), disease-related death (DRD), and overall survival time (OST) were analyzed with a Cox proportional hazards regression analysis.

Results

All cats were hypoglycemic on presentation with neurologic signs in 18 out of 20 and inappropriate insulin levels in 12/13. Excision of insulinomas resulted in immediate euglycemia or hyperglycemia in 18 cats. Eighteen cats survived to hospital discharge. The median time to death or last postoperative follow up was 664 days (range: 2-1205 days). Prognostic factors included age at presentation (for DFI); time to postoperative euglycemia (for DRD); preoperative and postoperative serum blood glucose concentrations; metastasis at the time of surgery (DFI and DRD), and histopathologic tumor invasion (for OST). The median OST for all cats was 863 days. The 1-, 2- and 3-year survival rates were 75%, 51%, and 10%, respectively.

Conclusion

Excision of insulinoma resulted in euglycemia or hyperglycemia in most cats. Negative prognostic factors included young age, low serum glucose concentrations, metastasis at time of surgery, tumor invasion, and shorter time to euglycemia.

Clinical significance

Surgical excision resulted in survival times comparable to those of canine INS.

SUBMITTER: Veytsman S

PROVIDER: S-EPMC10086986 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Retrospective study of 20 cats surgically treated for insulinoma.

Veytsman Stan S Amsellem Pierre P Husbands Brian D BD Rendahl Aaron K AK Bergman Philip J PJ Chanoit Guillaume G Hickey Colleen C Cash Kristy R KR Maritato Karl C KC Collivignarelli Francesco F Kirpensteijn Jolle J

Veterinary surgery : VS 20220920 1

<h4>Objective</h4>To report the clinical signs, histopathology results, and prognostic factors for outcomes following excision for feline insulinoma (INS).<h4>Study design</h4>Retrospective study.<h4>Sample population</h4>Twenty client-owned cats.<h4>Methods</h4>Medical records from 2006 to 2020 were reviewed by Veterinary Society of Surgical Oncology members for cats with hypoglycemia resulting from INS, with surgical excision and follow up. Clinical signs and histopathology results were summar ...[more]

PMID: 36124622

Similar Datasets

Project description:IntroductionThis retrospective study highlights the salient aspects of a series of feline patients affected with bisphosphonate related osteonecrosis of the jaw. Though more commonly published in human literature, this presentation is rare in cats. The authors hope that this study will assist in making this a more globally known entity with subsequent improved prognosis.MethodsData was retrospectively obtained from the medical records between 2015 and 2021 of 20 cats with Medication Related Osteonecrosis of the Jaw. Data included patient information, clinical history, presenting complaint, systemic diseases, details referable to hypercalcemia and treatment thereof, bisphosphonate specifics (dose and duration), clinical presentation of the lesion, diagnostic testing including radiographic and histopathologic descriptions, treatment, and outcome.ResultsPertinent results include that all 20 cats who developed Medication Related Osteonecrosis of the Jaw had been treated for idiopathic hypercalcemia with the bisphosphonate medication alendronate. Eighty-five percent of the cases had prior dental extractions at the site of MRONJ lesion. Ninety-five percent of the affected cats required a surgical procedure to control the disease. Thirty-five percent of cases required at least one revision surgery after the initial procedure was performed. Diagnosis of MRONJ was made by a correlation of diagnostic findings and patient history. No single diagnostic, or combination was pathognomonic for lesion diagnosis. As well, there were no statistically significant associations between patient variables assessed and the overall patient outcome.DiscussionThe case series reveals that cats with feline idiopathic hypercalcemia treated with alendronate may be at a risk for development of MRONJ, a serious oral condition with significant morbidity. Prior dental extraction sites in patients concurrently treated with bisphosphonate medications were often associated with MRONJ lesions. Therefore, any needed dental surgery should be performed prior to the use of bisphosphonates where possible. The authors have also included a relevant comparative literature review.

Project description:PurposeTrabecular Bone Score (TBS) is a software-based method for indirect assessment of trabecular bone structure of the spine, based on analysis of pixels in dual energy x-ray absorptiometry (DXA) images. Few studies describe the use of TBS in patients with primary hyperparathyroidism (PHPT). This study aimed at further describing this relationship, investigating possible correlations between biochemistry, body mass index (BMI), fracture incidence and TBS.MethodsCross-sectional study of 195 patients with verified PHPT, surgically (27) or conservatively (168) treated at the Department of Endocrinology, Aalborg University Hospital. TBS was acquired by reanalyzing DXA-images of the included subjects from the outpatient clinic. Biochemical variables were obtained from clinical routine blood samples taken in relation to the DXA-scans. History of fractures and medical history was obtained from radiology reports and medical charts.ResultsPatients with active PHPT had a TBS-score signifying a partly degraded bone structure, whereas surgically treated patients had a normal bone structure as judged by TBS, though the difference in TBS-score was not statistically significant. Use of antiresorptive treatment was negatively associated with BMD but not TBS. No correlations between the biochemical variables and TBS were found. A negative correlation between TBS and BMI in patients with PHPT was present. Patients experiencing a fragility fracture had a significantly lowered TBS, BMD and T-Score.ConclusionBiochemistry does not seem to predict bone status in terms of TBS in patients with PHPT. TBS is negatively correlated to BMI, which is also seen in patients not suffering from PHPT. The lack of a predictive value for antiresorptive treatment for TBS may raise concern. TBS appears to have a predictive value when assessing risk of fracture in patients with PHPT.Mini abstractThis cross-sectional study investigates possible correlations between biochemical variables, body mass index (BMI) and trabecular bone score (TBS) in 195 patients with primary hyperparathyroidism. It finds no correlation between biochemical variables and TBS, but finds a negative correlation between TBS and BMI and a clear association between fracture incidence and low TBS-score.

Project description:BackgroundAt present, the threshold defining older adults is 65 years, and this classification has been widely accepted globally. However, with the extension of both life expectancy and healthy life expectancy, there is a need to reconsider this age-based definition. This study compared the characteristics and surgical outcomes of older patients with lumbar spinal stenosis (LSS) between the early and late stages to clarify age diversity in this population.MethodsData collected from consecutive patients aged ≥ 65 years who underwent LSS surgery were retrospectively reviewed. All participants completed the Zurich Claudication Questionnaire, Japanese Orthopaedic Association Back Pain Evaluation Questionnaire (JOABPEQ), and 25-Question Geriatric Locomotive Function Scale preoperatively as well as 6 and 12 months postoperatively. Frailty was evaluated using the 11-point modified frailty index. Polypharmacy was defined as the concomitant use of at least six drugs.ResultsIn total, 311 older patients with LSS were enrolled. Among them, 136 patients younger than 75 were categorized into the E group, and 175 patients aged 75 and older were categorized into the L group. Baseline characteristics, including frailty and polypharmacy, significantly differed between the groups. The frequency of effective case of surgical treatment on JOABPEQ was significantly lower for walking ability in the L group. At 1 year after surgery, the incidence of non-improvement in locomotive syndrome stages was higher in the L group than in the E group (relative risk = 1.38, 95% confidence interval [CI] = 1.08-1.78). In addition, when the L group was further divided into three subgroups based on age, the relative risk was 1.32 (95% CI = 0.99-1.76) for patients aged 75 to < 80, 1.42 (95% CI = 1.07-1.88) for those aged 80 to < 85 years, and 1.68 (95% CI = 1.16-2.45) for those aged ≥ 85.ConclusionsSignificant differences were observed in baseline characteristics and postoperative improvement of walking ability and locomotive syndrome based on age among older patients with LSS. Our findings underscore the significant age diversity among older adults, highlighting the necessity of considering each patient in a more nuanced age-specific manner rather than adopting a one-size-fits-all approach.

Dataset Information

Retrospective study of 20 cats surgically treated for insulinoma.

Objective

Study design

Sample population

Methods

Results

Conclusion

Clinical significance

Publications

Retrospective study of 20 cats surgically treated for insulinoma.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets