Clinical performance of primary HPV screening cut-off for colposcopy referrals in HPV-vaccinated cohort: Observational study.

ABSTRACT:

Objective

To understand the effect of changing from cytology-based to primary HPV screening on the positive predictive value (PPV) of colposcopy referrals for cervical intraepithelial neoplasia (CIN) in a cohort offered HPV vaccination.

Design

Retrospective pre/post observational cohort study.

Setting

Scotland.

Population or sample

2193 women referred to colposcopy between September 2019 and February 2020 from cytology-based screening and between September 2020 and February 2021 from primary high-risk HPV (hrHPV) screening.

Methods

Calculating positive predictive values (PPVs) for two cohorts of women; one having liquid-based cytology screening and the other, the subsequent hrHPV cervical screening as a pre/post observational study.

Main outcome measu

SUBMITTER: Beecroft M 

PROVIDER: S-EPMC10087227 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature