Long-term changes in milk component immunoglobulins reflect milk oral immunotherapy outcomes in Finnish children.

ABSTRACT:

Background

Milk oral immunotherapy (OIT) may increase the amount of milk protein that can be ingested without triggering an allergic reaction. It is important to understand why some patients benefit from the treatment while others do not.

Objective

The aim was to define the differences in the milk allergen component-specific (casein, α-lactalbumin, ß-lactoglobulin) immunoglobulin (sIg [sIgE, sIgG4, and sIgA]) levels relative to the long-term outcomes of milk OIT.

Methods

In this long-term, open-label follow-up study, 286 children started milk OIT between 2005 and 2015. Follow-up data were collected at two points: the post-buildup phase and long term (range 1-11 years, median 6 years). Comparisons of sIg levels were made among three outcome groups of self-reported long

SUBMITTER: Kauppila TK 

PROVIDER: S-EPMC10087274 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature