Retrospective analysis of cancer-specific gene expression panel for thyroid fine needle aspiration specimens.

ABSTRACT:

Background

While molecular testing is a promising strategy for preoperative assessment of cytologically indeterminate thyroid nodules, thyroid fine needle aspiration biopsy (FNA) presents unique challenges for molecular assays, including contaminating peripheral blood mononuclear cells (PBMC) and variable numbers of evaluable epithelial thyroid cells. Moreover, the newly recognized entity, noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP), has added an additional challenge to the currently available molecular diagnostic platforms. New diagnostic tools are still needed to correctly distinguish benign and malignant thyroid nodules preoperatively.

Methods

Twenty-two transcript splice variants from 12 genes we previously identified as discrimin

SUBMITTER: Wang Y 

PROVIDER: S-EPMC10087285 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature