Dose optimization of cefotaxime as pre-emptive treatment in critically ill adult patients: A population pharmacokinetic study.

ABSTRACT:

Aims

To describe the pharmacokinetics (PK) of cefotaxime as pre-emptive treatment in critically ill adult patients, including covariates and to determine the probability of target attainment (PTA) of different dosage regimens for Enterobacterales and Staphylococcus aureus.

Methods

Five samples were drawn during 1 dosage interval in critically ill patients treated with cefotaxime 1 g q6h or q4h. PK parameters were estimated using NONMEM (v7.4.2). The percentage of patients reaching 100% fT>MIC_ECOFF was used to compare different dosage regimens for Enterobacterales and S. aureus.

Results

This study included 92 patients (437 samples). The best structural model was a 2-compartment model with a combined error, interindividual variability on clearance, central vo

SUBMITTER: Roelofsen EE 

PROVIDER: S-EPMC10087439 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature