Effect on haemostasis of different replacement fluids during therapeutic plasma exchange-A comparative multicentre observational study.

ABSTRACT:

Introduction

Therapeutic plasma exchange (TPE) is used for several chronic conditions with little evidence on the efficacy and safety of different choice of replacement fluid. Measurement of haemostasis, particularly in vitro thrombin generation, could play a role in determining the immediate efficacy of different fluid replacement.

Aim

To determine the impact of different TPE replacement fluid regimens on haemostatic assays.

Methods

Prospective observational multi-centre cohort study in adult patients 18 years and older evaluating haemostatic changes between four different TPE regimens: (1) 5% human albumin solution (Alb) only, (2) 50:50 mix of 5% Alb + modified gelatin, (3) 70:30 mix of 5% Alb and normal saline (NS), and (4) solvent-detergent, virus-inactivated fres

SUBMITTER: Kohli R 

PROVIDER: S-EPMC10087465 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature