Validated allergen exposure chamber is plausible tool for the assessment of house dust mite-triggered allergic rhinitis.

ABSTRACT:

Background

Allergen exposure chamber (AEC) is a clinical facility that allows exposure to allergenic airborne particles in controlled environment. Although AECs offer stable levels of airborne allergens, the validation of symptoms and other endpoints induced by allergen challenge is key for their recommendation as a plausible tool for the assessment of patients, especially in clinical research. This study aimed to demonstrate the reproducibility of defined clinical endpoints after AEC house dust mite (HDM) challenge under optimal conditions in patients with allergic rhinitis (AR).

Method

HDM was distributed at different concentrations. The assessment was subjective by the patients: total nasal symptom score (TNSS), visual analog scale (VAS), and objective by the investigator

SUBMITTER: Zemelka-Wiacek M 

PROVIDER: S-EPMC10087469 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature