Dataset Information

How adenomyosis changes throughout pregnancy: A retrospective cohort study.

ABSTRACT:

Objective

To study how adenomyosis changes during pregnancy and to possibly correlate these changes to maternal and fetal outcomes.

Methods

Retrospective exploratory cohort study including 254 women with a pre-conceptional/first-trimester scan to document adenomyosis and known obstetric outcome. If visible, adenomyosis signs were documented in each trimester and postpartum. Mann-Whitney U tests or χ² tests were used for continuous and categorical variables, respectively.

Results

A globular uterus was reported in 79% (n = 52) of women with adenomyosis in the first trimester, in 38% (n = 20) and 2% (n = 1) of women in the second and third trimesters, respectively, and postpartum in 77% (n = 34) of women. Asymmetrical thickening (n = 20, 30%) and cysts (n = 15, 23%) were only visible in 1st trimester. Adenomyosis was associated with miscarriage (odds ratio [OR] 5.9, 95% confidence interval [CI] 2.4-14.9, P < 0.001) also in normal conception only (OR 5.1, 95% CI 1.8-14.2, P = 0.002) or adjusting for maternal age (adjusted OR 5.9, 95% CI 2.3-15.2, P < 0.001). Gestational age at delivery was lower in adenomyosis (P = 0.004); the cesarean section rate was higher than in controls (OR 2.5, 95% CI 1.3-4.8, P = 0.007) also adjusting for age (adjusted OR 2.07, 95% CI 1.06-4.08, P = 0.035).

Conclusions

Signs of adenomyosis were visible but progressively disappeared in pregnancy; adenomyosis was associated with an increased risk of early miscarriage. Prospective studies are needed to confirm our results.

SUBMITTER: Bertucci E

PROVIDER: S-EPMC10087478 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature

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Publications

How adenomyosis changes throughout pregnancy: A retrospective cohort study.

Bertucci Emma E Sileo Filomena G FG Diamanti Marialaura M Alboni Carlo C Facchinetti Fabio F La Marca Antonio A

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20220817 3

<h4>Objective</h4>To study how adenomyosis changes during pregnancy and to possibly correlate these changes to maternal and fetal outcomes.<h4>Methods</h4>Retrospective exploratory cohort study including 254 women with a pre-conceptional/first-trimester scan to document adenomyosis and known obstetric outcome. If visible, adenomyosis signs were documented in each trimester and postpartum. Mann-Whitney U tests or χ<sup>2</sup> tests were used for continuous and categorical variables, respectively ...[more]

PMID: 35929196

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Dataset Information

How adenomyosis changes throughout pregnancy: A retrospective cohort study.

Objective

Methods

Results

Conclusions

Publications

How adenomyosis changes throughout pregnancy: A retrospective cohort study.

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