Transdiagnostic profiles of behaviour and communication relate to academic and socioemotional functioning and neural white matter organisation.

ABSTRACT:

Background

Behavioural and language difficulties co-occur in multiple neurodevelopmental conditions. Our understanding of these problems has arguably been slowed by an overreliance on study designs that compare diagnostic groups and fail to capture the overlap across different neurodevelopmental disorders and the heterogeneity within them.

Methods

We recruited a large transdiagnostic cohort of children with complex needs (N = 805) to identify distinct subgroups of children with common profiles of behavioural and language strengths and difficulties. We then investigated whether and how these data-driven groupings could be distinguished from a comparison sample (N = 158) on measures of academic and socioemotional functioning and patterns of global and local white matter connec

SUBMITTER: Mareva S 

PROVIDER: S-EPMC10087495 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature