Tonsillar transcriptional profiles in atopic and non-atopic subjects.

ABSTRACT:

Background

Emerging research suggests that local lymphatic tissue such as tonsils have important role in regulating the immune responses. However, allergen sensitization-induced alterations in transcriptome of tonsils are not known.

Objectives

To examine the key differences in tonsillar gene expression between atopic and non-atopic subjects and further by type of sensitization.

Methods

RNA-sequencing was performed on 52 tonsillar samples from atopic and non-atopic tonsillectomy patients. Sensitization to common food- and aero-allergen was defined by allergen specific IgE. Following groups were studied: (1) aero- and food-allergen sensitized (AS+FS) versus non-sensitized (NS), (2) aeroallergen-sensitized (AS) versus food-allergen sensitized (FS), (3) AS versus NS, (4)

SUBMITTER: Hanif T 

PROVIDER: S-EPMC10087516 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature