Time-restricted eating alters the 24-hour profile of adipose tissue transcriptome in men with obesity.

ABSTRACT:

Objective

Time-restricted eating (TRE) restores circadian rhythms in mice, but the evidence to support this in humans is limited. The objective of this study was to investigate the effects of TRE on 24-hour profiles of plasma metabolites, glucoregulatory hormones, and the subcutaneous adipose tissue (SAT) transcriptome in humans.

Methods

Men (n = 15, age = 63 [4] years, BMI 30.5 [2.4] kg/m² ) were recruited. A 35-hour metabolic ward stay was conducted at baseline and after 8 weeks of 10-hour TRE. Assessment included 24-hour profiles of plasma glucose, nonesterified fatty acid (NEFA), triglyceride, glucoregulatory hormones, and the SAT transcriptome. Dim light melatonin onset and cortisol area under the curve were calculated.

Results

TRE did not alter dim li

SUBMITTER: Zhao L 

PROVIDER: S-EPMC10087528 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature