Phase II proof-of-concept study of atorvastatin in castration-resistant prostate cancer.

ABSTRACT:

Objectives

To test for evidence of statin-mediated effects in patients with castration-resistant prostate cancer (CRPC) as post-diagnosis use of statins in patients with prostate cancer is associated with favourable survival outcome.

Patients and methods

The SPECTRE trial was a 6-weeks-long proof-of-concept single-arm Phase II treatment trial, combining atorvastatin and androgen deprivation therapy in patients with CRPC (regardless of metastatic status), designed to test for evidence of statin-mediated effects in patients with CRPC. The primary study endpoint was the proportion of patients achieving a ≥50% drop from baseline in prostate-specific antigen (PSA) levels at any time over the 6-week period of atorvastatin medication (PSA response). Exploratory endpoints include PS

SUBMITTER: Rushworth LK 

PROVIDER: S-EPMC10087532 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature