Laboratory biomarkers of delayed cerebral ischemia following subarachnoid hemorrhage: A systematic review.

ABSTRACT: Delayed cerebral ischemia (DCI) substantially contributes to disability and death in subarachnoid hemorrhage (SAH) patients; however, its pathophysiology is incompletely understood and diagnostic and therapeutic strategies are lacking. Biomarkers may help to elucidate the pathophysiology, optimize early diagnosis, or provide treatment targets. We systematically searched PubMed and Embase on October 13, 2021, for studies that evaluated at least one laboratory biomarker in patients with DCI, using the most up-to-date definition of DCI as proposed by a panel of experts in 2010. Quality of studies was assessed using the Newcastle-Ottawa Scale or Cochrane Collaboration's risk of bias assessment tool. Biomarkers of clinical and radiological DCI were analyzed separately. Results were meta-analyze

SUBMITTER: Tjerkstra MA 

PROVIDER: S-EPMC10087563 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature