Resensitization in suspected penicillin allergy.

ABSTRACT:

Background

The diagnosis of allergic reactions to penicillins (AR-PEN) is very complex as there is a loss of sensitization over time, which leads to negative skin tests (STs) and specific IgE in serum, and even to tolerance to the drug involved. However, STs may become positive after subsequent exposure to the culprit drug (resensitization), with the risk of inducing potentially severe reactions. The exact rate of resensitization to penicillins is unknown, ranging from 0% to 27.9% in published studies.

Objectives

To analyze the rate of resensitization in patients with suggestive AR-PEN by repeating STs (retest) after an initial evaluation (IE).

Material and methods

Patients with suspected AR-PEN were prospectively evaluated between 2017 and 2020. They underwent STs, a

SUBMITTER: Dona I 

PROVIDER: S-EPMC10087608 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature