The safety and performance of the Spectra Optia apheresis system platelet depletion protocol in patients with elevated platelet counts.

ABSTRACT:

Background

Thrombocytosis is a presenting and progressive clinical feature found in multiple disease states. It is characterized by high platelet (PLT) counts (>450 × 10⁹ /L) and can lead to thrombohemorrhagic events. Thrombocytapheresis or platelet depletion (PLTD) can be performed in acutely symptomatic patients suffering from thrombocytosis and may reduce or prevent acute serious complications associated with thrombocythemia thereby enabling patients to receive potentially curative high-dose chemotherapy.

Methods

This report details the results from 2 clinical studies, one conducted in the European Union (EU) and one in the People's Republic of China, assessing the PLTD procedure on the Spectra Optia Apheresis System. The primary objective of both studies was t

SUBMITTER: Lopert P 

PROVIDER: S-EPMC10087614 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature