CircSOBP Inhibits Bladder Cancer Proliferation and Metastasis by Regulating the miR-200a-3p/PTEN Axis and Participating in the Immune Response.

ABSTRACT: A growing body of evidence shows that circular RNAs (circRNAs) participate in tumor growth and metastasis and also play crucial roles in the treatment and prognosis of various cancers. In this article, we identified a novel circRNA, circSOBP (has_circ_0001633), based on the results of high-throughput RNA sequencing, and its expression was subsequently validated via quantitative reverse transcription polymerase chain reaction in bladder cancer (BCa) tissues and cell lines. The association between circSOBP expression and the clinicopathologic features and prognosis of 56 recruited BCa patients was then analyzed, and the biological roles of circSOBP were assessed by in vitro cloning formation, wound healing, transwell, CCK-8, and in vivo xenograft mouse models. Next, the competi

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC10087621 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature