Developing and validating a prediction model of adolescent major depressive disorder in the offspring of depressed parents.

ABSTRACT:

Background

Parental depression is common and is a major risk factor for depression in adolescents. Early identification of adolescents at elevated risk of developing major depressive disorder (MDD) in this group could improve early access to preventive interventions.

Methods

Using longitudinal data from 337 adolescents at high familial risk of depression, we developed a risk prediction model for adolescent MDD. The model was externally validated in an independent cohort of 1,384 adolescents at high familial risk. We assessed predictors at baseline and MDD at follow-up (a median of 2-3 years later). We compared the risk prediction model to a simple comparison model based on screening for depressive symptoms. Decision curve analysis was used to identify which model-predicted r

SUBMITTER: Stephens A 

PROVIDER: S-EPMC10087673 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature