The abundance of Ruminococcus bromii is associated with faecal butyrate levels and atopic dermatitis in infancy.

ABSTRACT:

Background

Impaired microbial development and decreased levels of short chain fatty acids, particularly butyrate, is suggested to have a role in the development of atopic dermatitis (AD).

Methods

Faecal microbiota composition, abundance of selected bacterial groups and fermentation metabolites were compared at 90, 180 and 360 days of life between 27 children who developed AD by age one (AD group), and 39 controls (non-AD group) among the CARE (Childhood AlleRgy, nutrition and Environment) study cohort.

Results

Diversity within the Firmicutes and Bacteroidetes phylum in the faecal microbiota was lower in the AD group compared to the non-AD group. Longitudinal analysis showed multiple amplicon sequence variants (ASV) within the same bacterial family to be differentially

SUBMITTER: Sasaki M 

PROVIDER: S-EPMC10087690 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature