Primary cutaneous peripheral T-cell lymphomas with a T-follicular helper phenotype: an integrative clinical, pathological and molecular case series study.

ABSTRACT:

Background

Primary cutaneous peripheral T-cell lymphomas with a T-follicular helper phenotype (pcTFH-PTCL) are poorly characterized, and often compared to, but not corresponding with, mycosis fungoides (MF), Sézary syndrome, primary cutaneous CD4⁺ lymphoproliferative disorder, and skin manifestations of angioimmunoblastic T-cell lymphomas (AITL).

Objectives

We describe the clinicopathological features of pcTFH-PTCL in this original series of 23 patients, and also characterize these cases molecularly.

Methods

Clinical and histopathological data of the selected patients were reviewed. Patient biopsy samples were also analysed by targeted next-generation sequencing.

Results

All patients (15 men, eight women; median age 66 years) presented with skin lesi

SUBMITTER: Wang L 

PROVIDER: S-EPMC10087773 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature