Analysis of the 24-h activity cycle: An illustration examining the association with cognitive function in the Adult Changes in Thought study.

ABSTRACT: The 24-h activity cycle (24HAC) is a new paradigm for studying activity behaviors in relation to health outcomes. This approach inherently captures the interrelatedness of the daily time spent in physical activity (PA), sedentary behavior (SB), and sleep. We describe three popular approaches for modeling outcome associations with the 24HAC exposure. We apply these approaches to assess an association with a cognitive outcome in a cohort of older adults, discuss statistical challenges, and provide guidance on interpretation and selecting an appropriate approach. We compare the use of the isotemporal substitution model (ISM), compositional data analysis (CoDA), and latent profile analysis (LPA) to analyze 24HAC. We illustrate each method by exploring cross-sectional associations with cognitio

SUBMITTER: Wu Y 

PROVIDER: S-EPMC10087899 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature