Dupilumab reduced impact of severe exacerbations on lung function in patients with moderate-to-severe type 2 asthma.

ABSTRACT:

Background

Severe asthma exacerbations increase the risk of accelerated lung function decline. This analysis examined the effect of dupilumab on forced expiratory volume in 1 s (FEV₁ ) in patients with moderate-to-severe asthma and elevated type 2 biomarkers from phase 3 LIBERTY ASTHMA QUEST (NCT02414854).

Methods

Changes from baseline in pre- and post-bronchodilator (BD) FEV₁ and 5-item Asthma Control Questionnaire (ACQ-5) scores were assessed in patients with elevated type 2 biomarkers at baseline (type 2-150/25: eosinophils ≥150 cells/μl and/or fractional exhaled nitric oxide [FeNO] ≥25 ppb; type 2-300/25: eosinophils ≥300 cells/μl and/or FeNO ≥25 ppb), stratified as exacerbators (≥1 severe exacerbation during the study) or non-exacerbators.

Resul

SUBMITTER: Papi A 

PROVIDER: S-EPMC10087924 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature