prolfqua: A Comprehensive R-Package for Proteomics Differential Expression Analysis.

ABSTRACT: Mass spectrometry is widely used for quantitative proteomics studies, relative protein quantification, and differential expression analysis of proteins. There is a large variety of quantification software and analysis tools. Nevertheless, there is a need for a modular, easy-to-use application programming interface in R that transparently supports a variety of well principled statistical procedures to make applying them to proteomics data, comparing and understanding their differences easy. The prolfqua package integrates essential steps of the mass spectrometry-based differential expression analysis workflow: quality control, data normalization, protein aggregation, statistical modeling, hypothesis testing, and sample size estimation. The package makes integrating new data fo

SUBMITTER: Wolski WE 

PROVIDER: S-EPMC10088014 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature