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A Chemical Strategy for the Preparation of Multimodified Peptide Imaging Probes.

ABSTRACT: Multimodality probes appear of great interest for innovative imaging applications in disease diagnosis. Herein, we present a chemical strategy enabling site-specific double-modification and cyclization of a peptide probe exploiting native chemical ligation (NCL) and thiol-maleimide addition. The synthetic strategy is straightforward and of general applicability for the development of double-labeled peptide multimodality probes.

SUBMITTER: De Rosa L

PROVIDER: S-EPMC10088022 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature

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A Chemical Strategy for the Preparation of Multimodified Peptide Imaging Probes.

De Rosa Lucia L Hawala Ivan I Di Stasi Rossella R Stefania Rachele R Capozza Martina M Nava Donatella D D'Andrea Luca Domenico LD

The Journal of organic chemistry 20230329 7

Multimodality probes appear of great interest for innovative imaging applications in disease diagnosis. Herein, we present a chemical strategy enabling site-specific double-modification and cyclization of a peptide probe exploiting native chemical ligation (NCL) and thiol-maleimide addition. The synthetic strategy is straightforward and of general applicability for the development of double-labeled peptide multimodality probes. ...[more]

PMID: 36988421

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