Ontology highlight
ABSTRACT:
SUBMITTER: Anselmi S
PROVIDER: S-EPMC10088026 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
Anselmi Silvia S Carvalho Alexandra T P ATP Serrano-Sanchez Angela A Ortega-Roldan Jose L JL Caswell Jill J Omar Iman I Perez-Ortiz Gustavo G Barry Sarah M SM Moody Thomas S TS Castagnolo Daniele D
ACS catalysis 20230323 7
Methionine sulfoxide reductase A (MsrA) enzymes have recently found applications as nonoxidative biocatalysts in the enantioselective kinetic resolution of racemic sulfoxides. This work describes the identification of selective and robust MsrA biocatalysts able to catalyze the enantioselective reduction of a variety of aromatic and aliphatic chiral sulfoxides at 8-64 mM concentration with high yields and excellent ees (up to 99%). Moreover, with the aim to expand the substrate scope of MsrA bioc ...[more]