Advanced glycation end-product accumulation differs by location and sex in aged osteoarthritic human menisci.

ABSTRACT:

Objective

There is a clear link between increasing age and meniscus degeneration, leading to increased injury, osteoarthritis (OA) progression, and often total knee replacement. Advanced glycation end-products (AGEs) are non-enzymatic crosslinks and adducts that accumulate in collagen with age, altering tissue mechanics and cell function, ultimately leading to increased injury and inflammation. AGEs, both fluorescent and non-fluorescent, play a central role in age-related degradation of tissues throughout the body; however, little is known about their role in meniscus degeneration. The objective of this study was to characterize changes in aged OA menisci, specifically evaluating zonal AGE accumulation, to gain a better understanding of changes that may lead to age-related meniscal

SUBMITTER: Gouldin AG 

PROVIDER: S-EPMC10088070 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature