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Iridium catalysed C2 site-selective methylation of indoles using a pivaloyl directing group through weak chelation-assistance† † Electronic supplementary information (ESI) available: Experimental details, NMR data, and spectra. See DOI: https://doi.org/10.1039/d3ra02031b

ABSTRACT: Here we present an iridium catalysed C2-selective methylation of indoles using methyltrifluoroborate as a source of methyl group. The iridium catalyst selectively discriminates the indole C2 and C4 C–H bonds by coordination with a pivaloyl directing group. Efficient iridium(iii) catalysed C2-selective methylation of indoles through the formation of a five-membered metallocycle is explored.

SUBMITTER: Kathiravan S

PROVIDER: S-EPMC10088075 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature

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