Associations of individual and cumulative urinary phthalate and replacement biomarkers with gestational weight gain through late pregnancy.

ABSTRACT:

Background/aims

Phthalates and their replacements are endocrine/metabolic disruptors that may impact gestational weight gain (GWG) - a pregnancy health indicator. We investigated overall and fetal sex-specific associations of individual and cumulative phthalate/replacement biomarkers with GWG.

Methods

Illinois women (n = 299) self-reported their weight pre-pregnancy and at their final obstetric appointment before delivery (median 38 weeks). We calculated pre-pregnancy body mass index and gestational age-specific GWG z-scores (GWGz). We quantified 19 phthalate/replacement metabolites (representing 10 parent compounds) in pools of up-to-five first-morning urine samples, collected approximately monthly between 8 and 40 weeks gestation. We used linear regression, quantile-based

SUBMITTER: Pacyga DC 

PROVIDER: S-EPMC10088088 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature