The identification and cognitive correlation of perfusion patterns measured with arterial spin labeling MRI in Alzheimer's disease.

ABSTRACT:

Background

Vascular dysfunction, including cerebral hypoperfusion, plays an important role in the pathogenesis and progression of Alzheimer's disease (AD), independent of amyloid and tau pathology. We established an AD-related perfusion pattern (ADRP) measured with arterial spin labeling (ASL) MRI using multivariate spatial covariance analysis.

Methods

We obtained multimodal MRI including pseudo-continuous ASL and neurocognitive testing in a total of 55 patients with a diagnosis of mild to moderate AD supported by amyloid PET and 46 normal controls (NCs). An ADRP was established from an identification cohort of 32 patients with AD and 32 NCs using a multivariate analysis method based on scaled subprofile model/principal component analysis, and pattern expression in individua

SUBMITTER: Meng M 

PROVIDER: S-EPMC10088108 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature