Sex differences in impact of cumulative systolic blood pressure from childhood to adulthood on albuminuria in midlife: a 30-year prospective cohort study.

ABSTRACT:

Background and objectives

Albuminuria is recognized as being a predictor of cardiovascular and renal disease. We aimed to identify the impact of the long-term burden and trends of systolic blood pressure on albuminuria in midlife, as well as to explore sex differences concerning this relationship.

Methods

This longitudinal study consisted of 1,683 adults who had been examined 4 or more times for blood pressure starting in childhood, with a follow-up time period of 30 years. The cumulative effect and longitudinal trend of blood pressure were identified by using the area under the curve (AUC) of individual systolic blood pressure measurement with a growth curve random effects model.

Results

Over 30 years of follow-up, 190 people developed albuminuria, including 53.2% ma

SUBMITTER: Wang D 

PROVIDER: S-EPMC10088136 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature