IPSC-derived cells lack immune tolerance to autologous NK-cells due to imbalance in ligands for activating and inhibitory NK-cell receptors.

ABSTRACT:

Background

Dozens of transplants generated from pluripotent stem cells are currently in clinical trials. The creation of patient-specific iPSCs makes personalized therapy possible due to their main advantage of immunotolerance. However, some reports have claimed recently that aberrant gene expression followed by proteome alterations and neoantigen formation can result in iPSCs recognition by autologous T-cells. Meanwhile, the possibility of NK-cell activation has not been previously considered. This study focused on the comparison of autologous and allogeneic immune response to iPSC-derived cells and isogeneic parental somatic cells used for reprogramming.

Methods

We established an isogeneic cell model consisting of parental dermal fibroblasts, fibroblast-like iPSC-derivativ

SUBMITTER: Bogomiakova ME 

PROVIDER: S-EPMC10088155 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature